YS2219 | ENPP1 inhibitor | Probechem Biochemicals

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Chemical Structure : YS2219

YS2219 (Compound 7)

Catalog No.: PC-27884Not For Human Use, Lab Use Only.

YS2219 is a highly potent and selective ENPP1 inhibitor with IC50 of 5.70 or 9.68 nM, shows weak inhibition against ENPP2 and ENPP3 (IC50>2500 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YS2219 is a highly potent and selective ENPP1 inhibitor with IC50 of 5.70 or 9.68 nM, shows weak inhibition against ENPP2 and ENPP3 (IC50>2500 nM).
YS2219 enhances the mRNA expression of cGAMP-induced STING pathway downstream target genes, such as IFNB1, CXCL10, and IL6.
YS2219 demonstartes enhancing the antitumor efficacy of the anti-PD-1 antibody in vivo.

Physicochemical Properties

M.Wt	557.58
Formula	C25H25F2N7O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-fluoro-2-(4-(sulfamoylamino)piperidin-1-yl)phenyl)-8-(2-fluoro-6-methoxyphenyl)imidazo[1,2-a]pyrazine-6-carboxamide

References

1. Shiping Zhan, et al. Discovery of Imidazo[1,2- a]pyrazine Derivatives as Potent ENPP1 Inhibitors. J Med Chem. 2024 Oct 24;67(20):18317-18333.

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YS2219 (Compound 7)

Biological Activity

Physicochemical Properties

References

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