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YS3375

Chemical Structure : YS3375

CAS No.:

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YS3375 (YS-3375)

Catalog No.: PC-27885Not For Human Use, Lab Use Only.

YS3375 is a potent and selective ENPP1 inhibitor with IC50 of 19.4 nM, shows weak to negligible ENPP2 and ENPP23 inhibition.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YS3375 is a potent and selective ENPP1 inhibitor with IC50 of 19.4 nM, shows weak to negligible ENPP2 and ENPP23 inhibition.
YS3375 enhanced cGAMP-induced expression of STING pathway genes (IFNB1, CXCL10, IL6) in a concentration-dependent manner without cytotoxicity.
YS3375 40 mg/kg) in combination with an anti-PD-1 antibody, achieved superior tumor growth inhibition, significantly prolonged survival in CT-26 colorectal cancer model.

Physicochemical Properties

M.Wt 506.42
Formula C23H22F3N4O4P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((1-(2-(6-(2,6-difluorophenyl)pyrazine-2-carboxamido)-4-fluorophenyl)piperidin-4-yl)methyl)phosphonic acid

References

1. He Z, et al. Eur J Med Chem. 2026 Aug 25;319:119274.

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