Chemical Structure : YSN-1-167
CAS No.:
YSN-1-167
Catalog No.: PC-27830Not For Human Use, Lab Use Only.
YSN-1-167 is a small molecule inhibitor of Enterovirus 71 (EV71) infection with IC50 of 11.66 uM (viral RNA detection), inhibits viral replication by suppressing 3D polymerase (3Dpol) activity of EV71.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YSN-1-167 is a small molecule inhibitor of Enterovirus 71 (EV71) infection with IC50 of 11.66 uM (viral RNA detection), inhibits viral replication by suppressing 3D polymerase (3Dpol) activity of EV71.
YSN-1-167 shows dose-dependent suppression of VP1 protein and viral RNA in Vero cells, with an IC50 of 9.64 μM.
YSN-1-167 exerts an antiviral effect by targeting the replication stage of the EV71 life cycle, but not the attachment and entry stages.
YSN-1-167 exerts anti-EV71 activity by inhibiting EV71 3D polymerase activity, potentially through interacting with the 3D protein.
YSN-1-167 significantly suppresses the inflammatory response induced by LPS treatment and EV71 infection.
YSN-1-167 (14 mg/kg) exerts anti-EV71 activity in mice, alleviates virus-induced muscle damage.
Physicochemical Properties
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M.Wt
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549.44
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Formula
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C23H22F4O4SSe
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(trifluoroseleninyl)propyl (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetate
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References
1. Qi Y, et al. Antimicrob Agents Chemother. 2026 Jul;70(7):e0186425.
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