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Chemical Structure : YT-6-2
Catalog No.: PC-23449Not For Human Use, Lab Use Only.
YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.
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YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.
YT-6-2 induces the biogenesis and recruitment of autophagic membranes to intracellular bacteria via SQSTM1, leading to lysosomal degradation.
YT-6-2 enhances host innate immunity against Mtb and other pathogens via SQSTM1-mediated xenophagy.
YT-6-2 (5-10 uM) dramatically inhibits the growth rate of Mtb in Mtb-infected BMDMs in CFU assays.
YT-6-2 (i.p. 20 mg/kg) enhance xenophagy-mediated host defense against pathogens in mice.
YT-6-2 inhibits the production of proinflammatory mediators in vitro and in vivo.
YT-6-2 also could be used as p62/SQSTM1 ligand for AUTOTAC design.
| M.Wt | 459.49 | |
| Formula | C25H27F2NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yoon Jee Lee, et al. Autophagy. 2022 Dec;18(12):2926-2945
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