Chemical Structure : YT-6-2
CAS No.:
2409959-90-4
YT-6-2
(YT 6-2)
Catalog No.: PC-23449Not For Human Use, Lab Use Only.
YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.
YT-6-2 induces the biogenesis and recruitment of autophagic membranes to intracellular bacteria via SQSTM1, leading to lysosomal degradation.
YT-6-2 enhances host innate immunity against Mtb and other pathogens via SQSTM1-mediated xenophagy.
YT-6-2 (5-10 uM) dramatically inhibits the growth rate of Mtb in Mtb-infected BMDMs in CFU assays.
YT-6-2 (i.p. 20 mg/kg) enhance xenophagy-mediated host defense against pathogens in mice.
YT-6-2 inhibits the production of proinflammatory mediators in vitro and in vivo.
YT-6-2 also could be used as p62/SQSTM1 ligand for AUTOTAC design.
Physicochemical Properties
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M.Wt
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459.49
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Formula
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C25H27F2NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-(3,4-bis((4-fluorobenzyl)oxy)phenoxy)-3-((2-hydroxyethyl)amino)propan-2-ol
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References
1. Yoon Jee Lee, et al. Autophagy. 2022 Dec;18(12):2926-2945
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