YTB53

Chemical Structure : YTB53

Catalog No.: PC-27034Not For Human Use, Lab Use Only.

YTB53 is a potent MNK (MAP kinase-interacting kinase) inhibitor with IC50 of 37 nM and 7 nM for MNK1/2 respectively, shows antiproliferative activity in MV4-11 cells with IC50 of 2 nM.

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Biological Activity

YTB53 is a potent MNK (MAP kinase-interacting kinase) inhibitor with IC50 of 37 nM and 7 nM for MNK1/2 respectively, shows antiproliferative activity in MV4-11 cells with IC50 of 2 nM.
YTB53 also significantly inhibits PDGFRα, TRKB and FLT3.
YTB53 induced cell cycle arrest, apoptosis, pyroptosis, and mitochondrial dysfunction.
YTB53 exhibited antiangiogenic effects and suppressed tumor growth in a xenograft model without overt toxicity.

Physicochemical Properties

M.Wt	303.32
Formula	C18H13N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(1H-indol-2-yl)oxazol-5-yl)benzamide

References

1. Chen X, et al. J Med Chem. 2026 Jun 1. doi: 10.1021/acs.jmedchem.6c00387.

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YTB53

Biological Activity

Physicochemical Properties

References

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