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YTX-465

Chemical Structure : YTX-465

CAS No.: 2225824-53-1

YTX-465 (YTX465;YTX 465)

Catalog No.: PC-35915Not For Human Use, Lab Use Only.

YTX-465 (YTX465) is a specific small molecule that rescues yeast from a-Syn cytotoxicity with EC50 of 15 nM, via inhibiting Ole1, the yeast homolog of human stearoyl-CoA desaturase (SCD).

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Biological Activity

YTX-465 (YTX465) is a specific small molecule that rescues yeast from a-Syn cytotoxicity with EC50 of 15 nM, via inhibiting Ole1, the yeast homolog of human stearoyl-CoA desaturase (SCD).
YTX-465 is inactive at SCD1.

Physicochemical Properties

M.Wt 458.522
Formula C25H26N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(4-(3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-2-oxoethyl)benzamide

References

1. Vincent BM, et al. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.

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