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Chemical Structure : YU 238259
CAS No.: 1943733-16-1
Catalog No.: PC-62268Not For Human Use, Lab Use Only.
YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects.
YU 238259 specifically inhibits homology-dependent DNA repair (HDR), but not non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
YU 238259 significantly delays tumor growth of BRCA2-deficient human tumor xenografts in nude mice.
| M.Wt | 459.95 | |
| Formula | C22H22ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[2-(5-Chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]benzamide |
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1. Stachelek GC, et al. Mol Cancer Res. 2015 Oct;13(10):1389-97.
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