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YW2065

Chemical Structure : YW2065

CAS No.: 2131223-85-1

YW2065 (YW-2065)

Catalog No.: PC-49509Not For Human Use, Lab Use Only.

YW2065 is is a small molecule inhibitor of Wnt signaling by stabilizing Axin-1, also activates the tumor suppressor AMPK, demonstratesexcellent anti-CRC effects in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

YW2065 is is a potent, selective inhibitor of Wnt signaling by stabilizing Axin-1 with IC50 of 2.3 nM in Wnt-HEK293 luciferase gene reporter assays, also activates the tumor suppressor AMPK.
YW2065 demonstrated good potencies in killing human CRC SW480 cells with IC50 of 2.4 uM.
YW2065 activated AMPK through phosphorylation, which in turn led to the phosphorylation of the downstream substrate acetyl-CoA carboxylase (ACC) in a dose-dependent manner.
YW2065 inhibited CRC cell proliferation and growth in vitro.
YW2065 (10 or 50 mg/kg, i.p.) suppressed SW620 tumor growth in vivo.

Physicochemical Properties

M.Wt 407.27
Formula C20H15BrN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2-bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide

References

1. Wei Yang, et al. J Med Chem. 2019 Dec 26;62(24):11151-11164.

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