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YW4-03

Chemical Structure : YW4-03

CAS No.: 1374311-13-3

YW4-03

Catalog No.: PC-23134Not For Human Use, Lab Use Only.

YW4-03 is a small molecule peptidylarginine deiminase (PAD) inhibitor with IC50 of 5 uM against PAD4, exhibits cell-killing efficacy in osteosarcoma U2OS cells with IC50 of 2.5-5 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YW4-03 is a small molecule peptidylarginine deiminase (PAD) inhibitor with IC50 of 5 uM against PAD4, exhibits cell-killing efficacy in osteosarcoma U2OS cells with IC50 of 2.5-5 uM.

Physicochemical Properties

M.Wt 477.01
Formula C27H29ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(1-(benzylamino)-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)-[1,1'-biphenyl]-3-carboxamide

References

1. Yuji Wang, et al. J Biol Chem. 2012 Jul 27;287(31):25941-53.

2. Lai Shi, et al. Mol Cancer Res. 2020 May;18(5):735-747.

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