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Chemical Structure : YY002
Catalog No.: PC-22095Not For Human Use, Lab Use Only.
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation.
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YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation.
YY002 strongly suppresses STAT3 nuclear and mitochondrial functions in STAT3-dependent cells.
YY002 also shows no obvious inhibition on tyrosine kinases or serine kinases.
YY002 potently suppresses pancreatic cancer cells with high pSTAT3 (Tyr705 and Ser727) with IC50 of 3-11 nM.
YY002 inhibitscolony formation of multiple STAT3-dependent PDAC cells at concentration of 1 to 10 nM.
YY002 inhibits STAT3 Ser727 phosphorylation and mitochondrial OXPHOS.
YY002 (5 mg/kg/d to 20 mg/kg/d, oral) inhibits pancreatic cancer growth in PANC-1 tumor mouse xenograft models.
| M.Wt | 737.66 | |
| Formula | C36H29F6N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang Chen, et al. ACS Cent Sci. 2024 Feb 10;10(3):579-594.
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