YY2201

Chemical Structure : YY2201

Catalog No.: PC-24257Not For Human Use, Lab Use Only.

YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR.

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Biological Activity

YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR.
YY2201 efficiently inhibits tumor progression in broad-spectrum cancer types, YY2201 could dose-dependently induce G2 arrest of the cell cycle in Lovo cells, inhibits DDR and induces cell cycle arrest and apoptosis in cancer cells.
YY2201 shows superior in vivo anticancer efficacy and a better therapeutic index compared to AZD6738 in a lung cancer xenograft model.
YY2201 also exhibits potent cancer suppression effects in combination with chemotherapy in vivo.

Physicochemical Properties

M.Wt	467.54
Formula	C25H25N9O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(7-(3,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-oxa-3-azabicyclo[3.2.1]octane

References

1. Wu M, et al. J Med Chem. 2025 Mar 13;68(5):5292-5311.

YY2201

Biological Activity

Physicochemical Properties

References

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