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YYA-021

Chemical Structure : YYA-021

CAS No.: 144217-65-2

YYA-021 (YYA 021;YYA021)

Catalog No.: PC-42047Not For Human Use, Lab Use Only.

A small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 9 uM against YTA48P virus with no significant cytotoxicity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 9 uM against YTA48P virus with no significant cytotoxicity; shows wide tissue distribution and relatively high distribution volumes, and has promise for intravenous administration.

Physicochemical Properties

M.Wt 317.4259
Formula C18H27N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethanediamide, N1-(4-methylphenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-

References

1. Hashimoto C, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7884-9.

2. Otsuki H, et al. J Gen Virol. 2013 Dec;94(Pt 12):2710-6.

3. Narumi T, et al. Bioorg Med Chem. 2013 May 1;21(9):2518-26.

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