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Yhhu-3792

Chemical Structure : Yhhu-3792

CAS No.: 2097826-24-7

Yhhu-3792 (Yhhu3792)

Catalog No.: PC-63504Not For Human Use, Lab Use Only.

Yhhu-3792 is a novel small molecule that enhances the self-renewal capability of neural stem cells (NSCs) in vitro and in vivo via activating the Notch signaling pathway.

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    Biological Activity

    Yhhu-3792 is a novel small molecule that enhances the self-renewal capability of neural stem cells (NSCs) in vitro and in vivo via activating the Notch signaling pathway.
    Yhhu-3792 activates Notch signaling pathway and promotes the expression of Notch target genes, Hes3 and Hes5.
    Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice.

    Physicochemical Properties

    M.Wt 400.482
    Formula C24H24N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N2-(4-isopropylphenyl)-5-(3-methoxyphenoxy)quinazoline-2,4-diamine

    References

    1. Hui L, et al. Stem Cells. 2018 May 3. doi: 10.1002/stem.2843.

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