You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Yonkenafil
Yonkenafil

Chemical Structure : Yonkenafil

CAS No.: 804518-63-6

Yonkenafil (Tunodafil)

Catalog No.: PC-38810Not For Human Use, Lab Use Only.

Yonkenafil (Tunodafil) is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM.

Packing Price Stock Quantity
5 mg $188 In stock
10 mg $298 In stock
25 mg $488 In stock
50 mg $788 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Yonkenafil (Tunodafil) is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM.
Yonkenafil inhibits microglial activation by decreasing PDE-5 expression and increasing the cGMP level.
Yonkenafil induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke.
Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model.

Physicochemical Properties

M.Wt 487.619
Formula C24H33N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

References

1. Chen X, et al. Exp Neurol. 2014 Nov;261:267-77.

2. Zhu L, et al. Mech Ageing Dev. 2015 Sep;150:34-45.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: