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Chemical Structure : Z-360
CAS No.: 209219-38-5
Catalog No.: PC-45389Not For Human Use, Lab Use Only.
Z-360 (Nastorazepide) is a novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $268 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Z-360 (Nastorazepide) is a novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.
Z-360 significantly reduces gastrin-induced PKB/Akt phosphorylation in human CCK-2 receptor-expressing cells.
Z-360 significantly inhibits the growth of MiaPaCa2, also suppresses pancreatic tumor growth and prolong survival in a pancreatic carcinoma xenograft model combined with gemcitabine.
Z-360 prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice.
| M.Wt | 520.6199 | |
| Formula | C29H36N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 3-[[[[(3R)-5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2,3,4,5-tetrahydro-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]- |
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1. Kawasaki D, et al. Cancer Chemother Pharmacol. 2008 Apr;61(5):883-92.
2. Meyer T, et al. Eur J Cancer. 2010 Feb;46(3):526-33.
3. Orikawa Y, et al. Mol Pain. 2010 Oct 28;6:72.
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