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Chemical Structure : Z-Ile-Leu-aldehyde
CAS No.: 161710-10-7
Catalog No.: PC-43045Not For Human Use, Lab Use Only.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $218 | In stock | |
| 5 mg | $328 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote |
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Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) induces morphologic erythroid differentiation and promotes hemoglobin production, suppresses short-term growth and colony formation in erythroid leukemia cell lines.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) impairs murine osteoclast differentiation of RANKL-stimulated RAW264.7 cells in vitro.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) exhibits potent anti-MM activity and reduces osteolytic lesions in he murine myeloma model.
| M.Wt | 362.4632 | |
| Formula | C20H30N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester |
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1. Okuhashi Y, et al. Anticancer Res. 2010 Oct;30(10):4071-4.
2. Nwabo Kamdje AH, et al. Blood. 2011 Jul 14;118(2):380-9.
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