Chemical Structure : Z-Ile-Leu-aldehyde
CAS No.:
161710-10-7
Z-Ile-Leu-aldehyde
(Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII)
Catalog No.: PC-43045Not For Human Use, Lab Use Only.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
| Packing | Price | Stock | Quantity |
| 2 mg | $218 | In stock | |
| 5 mg | $328 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | | Get quote | |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Select Batch:
Biological Activity
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) induces morphologic erythroid differentiation and promotes hemoglobin production, suppresses short-term growth and colony formation in erythroid leukemia cell lines.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) impairs murine osteoclast differentiation of RANKL-stimulated RAW264.7 cells in vitro.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) exhibits potent anti-MM activity and reduces osteolytic lesions in he murine myeloma model.
Physicochemical Properties
|
M.Wt
|
362.4632
|
|
Formula
|
C20H30N2O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
DMSO: ≥ 41 mg/mL
|
|
Chemical Name/SMILES
|
Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester
|
References
1. Okuhashi Y, et al. Anticancer Res. 2010 Oct;30(10):4071-4.
2. Nwabo Kamdje AH, et al. Blood. 2011 Jul 14;118(2):380-9.
Contact Us
sales@probechem.com
