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Z-Tyr-Ala-CHN2

Chemical Structure : Z-Tyr-Ala-CHN2

CAS No.: 114515-99-0

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Z-Tyr-Ala-CHN2

Catalog No.: PC-20410Not For Human Use, Lab Use Only.

Z-Tyr-Ala-CHN2 is a potent cathepsin L inhibitor with EC50 of <50 nM, has broad-spectrum coronavirus antiviral activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Z-Tyr-Ala-CHN2 is a potent cathepsin L inhibitor with EC50 of <50 nM, has broad-spectrum coronavirus antiviral activity.
    Z-Tyr-Ala-CHN2 showed activity against SARS-CoV-1 and HCoV-229E, with EC50 of 0.050 and 0.069 µM, respectively.
    Z-Tyr-Ala-CHN2 potently inhibit infection in SARS-CoV-2 both A549-hACE2 and HeLa-hACE2 cells with EC50 of 0.046 and 0.006 uM, with no effect in Caco-2 cells.
    Z-Tyr-Ala-CHN2 acts on the endosomal entry pathway in pseudotyped SARS-CoV-2 neutralization assay in VeroE6 cells.

    Physicochemical Properties

    M.Wt 410.43
    Formula C21H22N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    benzyl ((S)-1-(((S)-4-diazo-3-oxobutan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

    References

    1. Jordi Doijen, et al. Microorganisms. 2023 Mar 10;11(3):717.

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