ZB-R-55 | RIPK1 inhibitor | Probechem Biochemicals

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Chemical Structure : ZB-R-55

ZB-R-55 (RIPK1 inhibitor)

Catalog No.: PC-72473Not For Human Use, Lab Use Only.

ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772.
ZB-R-55 is a dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets.
ZB-R-55 exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model.

Physicochemical Properties

M.Wt	441.491
Formula	C25H23N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-benzyl-N-(7-(cyclopropylethynyl)-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide

References

1. Xiangbo Yang, et al. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114922.

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