ZBMA-1 |CAS:1975145-64-2 Probechem Biochemicals

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Chemical Structure : ZBMA-1

ZBMA-1 (ZBMA1)

Catalog No.: PC-36113Not For Human Use, Lab Use Only.

ZBMA-1 is a potent HIV-1 replication inhibitor (IC50=1.01 uM) that efficiently protects APOBEC3G protein by targeting Vif-APOBEC3G complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZBMA-1 is a potent HIV-1 replication inhibitor (IC50=1.01 uM) that efficiently protects APOBEC3G protein by targeting Vif-APOBEC3G complex.
ZBMA-1 protected APOBEC3G from Vif-mediated degradation in a dose-dependent manner and induced nonfunctional proviruses, blocked Vif binding to Elongin C.
ZBMA-1 does not affect the interactions between Vif and APOBEC3G or CBF-β.

Physicochemical Properties

M.Wt	325.169
Formula	C15H9BrN4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1H-benzo[d]imidazol-2-yl)-3-(6-bromopyridin-3-yl)acrylonitrile

References

1. Zhang S, et al. Antiviral Res. 2015 Oct;122:20-7.

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ZBMA-1 (ZBMA1)

Biological Activity

Physicochemical Properties

References

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