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ZCAN262

Chemical Structure : ZCAN262

CAS No.:

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ZCAN262 (ZCAN 262)

Catalog No.: PC-21623Not For Human Use, Lab Use Only.

ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
    ZCAN262 (2.5-5 mg/kg. p.o.) significantly improves motor function in the EAE and cuprizone-diet models for MS.
    ZCAN262 restores myelination, axon integrity, and oligodendrocytes in the cuprizone-diet mouse model for multiple sclerosis (MS).
    ZCAN262 can improve MS pathology without disrupting basal synaptic transmission or measures of recognition memory and spatial learning.

    Physicochemical Properties

    M.Wt 384.39
    Formula C19H18F2N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(2,4-difluorobenzyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)-N,N-dimethylpyrimidine-4-carboxamide

    References

    1. Zhai D, et al. Sci Adv. 2023 Dec 8;9(49):eadj6187.

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