Catalog No.: PC-21623Not For Human Use, Lab Use Only.
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
ZCAN262 (2.5-5 mg/kg. p.o.) significantly improves motor function in the EAE and cuprizone-diet models for MS.
ZCAN262 restores myelination, axon integrity, and oligodendrocytes in the cuprizone-diet mouse model for multiple sclerosis (MS).
ZCAN262 can improve MS pathology without disrupting basal synaptic transmission or measures of recognition memory and spatial learning.
