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Chemical Structure : ZCAN262
Catalog No.: PC-21623Not For Human Use, Lab Use Only.
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
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ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
ZCAN262 (2.5-5 mg/kg. p.o.) significantly improves motor function in the EAE and cuprizone-diet models for MS.
ZCAN262 restores myelination, axon integrity, and oligodendrocytes in the cuprizone-diet mouse model for multiple sclerosis (MS).
ZCAN262 can improve MS pathology without disrupting basal synaptic transmission or measures of recognition memory and spatial learning.
| M.Wt | 384.39 | |
| Formula | C19H18F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhai D, et al. Sci Adv. 2023 Dec 8;9(49):eadj6187.
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