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Chemical Structure : ZD7114
Catalog No.: PC-21223Not For Human Use, Lab Use Only.
ZD7114 (ICI D7114) is a potent, selective beta-adrenoceptor agonist, selectively stimulates brown fat and increases whole-body oxygen consumption.
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ZD7114 (ICI D7114) is a potent, selective beta-adrenoceptor agonist, selectively stimulates brown fat and increases whole-body oxygen consumption.
Treatment of rats with ICI D7114 stimulated oxygen consumption (ED50, 0.04 mg kg-1, p.o.) and BAT mitochondrial guanosine diphosphate (GDP)-binding (ED50, 0.15 mg kg-1, p.o.) with no chronotropic effects on the heart at these doses.
ZD7114 has activity at atypical beta-adrenoceptors in brown adipose tissue leading to increased whole body oxygen consumption.
| M.Wt | 418.49 | |
| Formula | C22H30N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Holloway BR, et al. Br J Pharmacol. 1991 Sep;104(1):97-104.
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