ZD7114 | beta-adrenoceptor agonist | Probechem Biochemicals

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Chemical Structure : ZD7114

ZD7114 (ICI D7114, ZD 7114)

Catalog No.: PC-21223Not For Human Use, Lab Use Only.

ZD7114 (ICI D7114) is a potent, selective beta-adrenoceptor agonist, selectively stimulates brown fat and increases whole-body oxygen consumption.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZD7114 (ICI D7114) is a potent, selective beta-adrenoceptor agonist, selectively stimulates brown fat and increases whole-body oxygen consumption.
Treatment of rats with ICI D7114 stimulated oxygen consumption (ED50, 0.04 mg kg-1, p.o.) and BAT mitochondrial guanosine diphosphate (GDP)-binding (ED50, 0.15 mg kg-1, p.o.) with no chronotropic effects on the heart at these doses.
ZD7114 has activity at atypical beta-adrenoceptors in brown adipose tissue leading to increased whole body oxygen consumption.

Physicochemical Properties

M.Wt	418.49
Formula	C22H30N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-[2-Hydroxy-3-phenoxypropylaMinoethoxy]-N-(2-Methoxyethyl)phenoxyacetaMide

References

1. Holloway BR, et al. Br J Pharmacol. 1991 Sep;104(1):97-104.

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ZD7114 (ICI D7114, ZD 7114)

Biological Activity

Physicochemical Properties

References

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