Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ZE132
Catalog No.: PC-72764Not For Human Use, Lab Use Only.
ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
ZE132 effectively inhibits the PD-1/PD-L1 interactions in vitro, and has a potent affinity to PD-L1.
ZE132 shows robust anti-tumour effects in vivo, better than anti-PD-1 antibody.
ZE132 treatment promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression.
ZE132 elicits strong inhibitory effects on the mRNA expression of TGF-β.
| M.Wt | 721.266 | |
| Formula | C37H41ClN4O7S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Chenglong Liu, et al. Br J Pharmacol. 2021 Jul;178(13):2651-2670.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
