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Chemical Structure : ZE132
Catalog No.: PC-72764Not For Human Use, Lab Use Only.
ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
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ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
ZE132 effectively inhibits the PD-1/PD-L1 interactions in vitro, and has a potent affinity to PD-L1.
ZE132 shows robust anti-tumour effects in vivo, better than anti-PD-1 antibody.
ZE132 treatment promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression.
ZE132 elicits strong inhibitory effects on the mRNA expression of TGF-β.
| M.Wt | 721.266 | |
| Formula | C37H41ClN4O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chenglong Liu, et al. Br J Pharmacol. 2021 Jul;178(13):2651-2670.
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