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ZE132

Chemical Structure : ZE132

CAS No.: 2566710-63-0

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ZE132 (ZE 132)

Catalog No.: PC-72764Not For Human Use, Lab Use Only.

ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
    ZE132 effectively inhibits the PD-1/PD-L1 interactions in vitro, and has a potent affinity to PD-L1.
    ZE132 shows robust anti-tumour effects in vivo, better than anti-PD-1 antibody.
    ZE132 treatment promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression.
    ZE132 elicits strong inhibitory effects on the mRNA expression of TGF-β.

    Physicochemical Properties

    M.Wt 721.266
    Formula C37H41ClN4O7S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((5-Chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(3-(dimethylamino)propyl)amino)ethane-1-sulfonic acid

    References

    1. Chenglong Liu, et al. Br J Pharmacol. 2021 Jul;178(13):2651-2670.

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