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ZG-2585

Chemical Structure : ZG-2585

CAS No.:

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ZG-2585 (ZG2585)

Catalog No.: PC-27331Not For Human Use, Lab Use Only.

ZG-2585 is a potent and selective, orally active Thyroid hormone receptor β (THRβ) agonist with EC50 of 1.24 uM, shows 5-fold selectivity against THRα, improves body weight, hepatic steatosis and lipid accumulation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZG-2585 is a potent and selective, orally active Thyroid hormone receptor β (THRβ) agonist with EC50 of 1.24 uM, shows 5-fold selectivity against THRα, improves body weight, hepatic steatosis and lipid accumulation.

Physicochemical Properties

M.Wt 400.21
Formula C16H15Cl2N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)benzoyl)glycine

References

1. Wu Y, et al. J Med Chem. 2026 Jul 16. doi: 10.1021/acs.jmedchem.6c01599.

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