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Chemical Structure : ZGN-1061
Catalog No.: PC-63184Not For Human Use, Lab Use Only.
ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity.
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ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP-2) inhibitor being investigated for treatment of diabetes and obesity.
ZGN-1061 reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib.
ZGN-1061 does not increase coagulation markers in dogs and ZGN-1061 has a greatly improved safety profile in rats relative to beloranib.
| M.Wt | 478.63 | |
| Formula | C26H42N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272.
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