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ZGN-1061

Chemical Structure : ZGN-1061

CAS No.: 2082752-83-6

ZGN-1061 (Aclimostat;ZGN1061)

Catalog No.: PC-63184Not For Human Use, Lab Use Only.

ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP-2) inhibitor being investigated for treatment of diabetes and obesity.
    ZGN-1061 reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib.
    ZGN-1061 does not increase coagulation markers in dogs and ZGN-1061 has a greatly improved safety profile in rats relative to beloranib.

    Physicochemical Properties

    M.Wt 478.63
    Formula C26H42N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3- methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl 3-[2-(morpholin-4-yl)ethyl]azetidine-1-carboxylate

    References

    1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272.

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