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ZH07

Chemical Structure : ZH07

CAS No.: 2688035-27-8

ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24)

Catalog No.: PC-73236Not For Human Use, Lab Use Only.

ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.
    ZH07 displays appreciable selectivity (>250-fold) over Bcl-2/Bcl-xL.
    ZH07 induces dose-dependent disruption of interactions between BL-Bim and endogenous Mcl-1 and Bfl-1, without affecting the complexes between BL-Bim and Bcl-2 or Bcl-xL.
    ZH07 demonstrates on-target cellular activity in model lymphoma cell lines.

    Physicochemical Properties

    M.Wt 567.763
    Formula C30H37N3O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((4-(4-(tert-butyl)benzyl)piperazine)-1-sulfonamido)-5-(phenethylthio)benzoic acid

    References

    1. Xuexin Feng, et al. European Journal of Medicinal Chemistry 236 (2022) 114327

    2. Karson J Kump, et al. J Med Chem. 2020 Mar 12;63(5):2489-2510.

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