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Chemical Structure : ZH97
Catalog No.: PC-73235Not For Human Use, Lab Use Only.
ZH97 is a selective and covalent small-molecule inhibitor of BFL-1 protein with binding Ki of 0.41 uM, >200-fold selectivity over MCL-1.
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ZH97 is a selective and covalent small-molecule inhibitor of BFL-1 protein with binding Ki of 0.41 uM, >200-fold selectivity over MCL-1.
ZH97 does not bind to BCL-xL, BCL-2, TEAD2, TEAD4, MDM2, MDMX, BRD2 BD1, BRD2 BD2, BRD3 BD1, BRD3 BD2, BCL9, PD1/PD-L1 (Ki>400 uM).
ZH97 modifies BFL-1 at the C55 residue, blocks BFL-1/BID interaction in vitro.
ZH97 dose-dependently increased cytoplasmic cytochrome c level in U937 cells, has cell growth inhibition with IC50 of 2.8 uM, 5.5 uM, 7.7 uM, 6.8 uM, and 3.9 uM in U937, Kasumi-1, K562, MM.1S, and MV4-11 cell lines, respectively.
ZH97 inhibits BFL-1/PUMA interaction in cell lysate and is effective in cancer cells that harboring high
expression level of BFL-1.
| M.Wt | 440.522 | |
| Formula | C27H25FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xuexin Feng, et al. European Journal of Medicinal Chemistry 236 (2022) 114327
2. Karson J Kump, et al. J Med Chem. 2020 Mar 12;63(5):2489-2510.
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