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ZHAWOC21026

Chemical Structure : ZHAWOC21026

CAS No.: 2383037-14-5

ZHAWOC21026 (ZHAWOC 21026)

Catalog No.: PC-73387Not For Human Use, Lab Use Only.

ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.

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    Biological Activity

    ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.
    ZHAWOC21026 demonstrated highly potent inhibitory activity against A75/17-CDV, PIV-5, RSV, and NiV in corresponding cells (IC50<80 nM).
    ZHAWOC21026 inhibits the replication via the RdRp complex but, however in a host-directed manner, which in turn prohibits the emergence of resistant mutants.

    Physicochemical Properties

    M.Wt 372.483
    Formula C20H24N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-methyl-N-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide

    References

    1. Shrestha N, et al. mBio. 2021 Dec 21;12(6):e0262121.

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