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Chemical Structure : ZHAWOC21026
Catalog No.: PC-73387Not For Human Use, Lab Use Only.
ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.
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ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.
ZHAWOC21026 demonstrated highly potent inhibitory activity against A75/17-CDV, PIV-5, RSV, and NiV in corresponding cells (IC50<80 nM).
ZHAWOC21026 inhibits the replication via the RdRp complex but, however in a host-directed manner, which in turn prohibits the emergence of resistant mutants.
| M.Wt | 372.483 | |
| Formula | C20H24N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shrestha N, et al. mBio. 2021 Dec 21;12(6):e0262121.
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