Chemical Structure : ZHSI-1 hydrochloride
CAS No.:
ZHSI-1 hydrochloride
Catalog No.: PC-21423Not For Human Use, Lab Use Only.
ZHSI-1 hydrochloride is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZHSI-1 hydrochloride is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.
ZHSI-1 significantly reduced EV71 and CVA16 RNA replication and viral titers in a dose-dependent manner in infected RD cells.
ZHSI-1 significantly inhibits the localization of 3D and PI4KB on the lysosomal surface and inhibited the colocalization of 3D and RagB.
ZHSI-1 also inhibits EV71-induced pyroptosis in EV71-infected RD cells.
ZHSI-1 hydrochloride (30 mg/kg) inhibits EV71 replication and viral pathogenesis in EV71-695F-infected mice, efficiently reduces the levels of EV71-695F RNA in the liver, brain, and muscles of mice.
Physicochemical Properties
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M.Wt
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329.83
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Formula
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C17H20ClN5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N2-isopropyl-6-methyl-N4-(quinolin-6-yl)pyrimidine-2,4-diamine hydrochloride
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References
1. Wang X, et al. J Cell Biol. 2023 Dec 4;222(12):e202303108.
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