Chemical Structure : ZINC000443438219
CAS No.:
2761358-29-4
ZINC000443438219
(Compound 8291)
Catalog No.: PC-20766Not For Human Use, Lab Use Only.
ZINC000443438219 (Compound 8219) is a highly potent, selective and non-competitive inhibitor of serotonin transporter (SERT) with Ki of 3 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZINC000443438219 (Compound 8219) is a highly potent, selective and non-competitive inhibitor of serotonin transporter (SERT) with Ki of 3 nM.
ZINC000443438219 (Compound 8219) does not preferentially stabilize an open cytoplasmic pathway but like ibogaine and unlike classic SSRIs they decrease the accessibility of the extracellular pathway.
ZINC000443438219 (Compound 8219) is to close the extracellular pathway, with little or no effect on the cytoplasmic pathway.
ZINC000443438219 (Compound 8219) is selective versus NET, DAT, and ~300 GPCR targets.
ZINC000443438219 (Compound 8219) (10 mg/kg) chronically injected in mice produced an anti-anxiolytic-like effect in the plus-maze test.
Physicochemical Properties
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M.Wt
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291.39
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Formula
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C15H18FN3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-2-(2,4-dimethylpiperazin-1-yl)-4-(4-fluorophenyl)thiazole
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References
1. Isha Singh, et al. Cell. 2023 Apr 28;S0092-8674(23)00406-3.
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