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ZJU-37

Chemical Structure : ZJU-37

CAS No.: 2408587-59-5

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ZJU-37 (ZJU37)

Catalog No.: PC-38621Not For Human Use, Lab Use Only.

ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.
    ZJU-37 promotes oligodendrocyte progenitor cells (OPCs) proliferation in vitro with higher efficacy than Nec-1s, enhances remyelination in vivo.
    ZJU-37 promotes transcription of PDGFRα and proliferation of OPCs via NF-κB.

    Physicochemical Properties

    M.Wt 323.708
    Formula C14H11ClFN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-((7-chloro-6-fluoro-1H-indol-3-yl)methyl)-3-methyl-2,4-dioxoimidazolidine-1-carbaldehyde

    References

    1. Xiao-Ru Ma, et al. Cell Death Discov. 2022 Apr 1;8(1):147.

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