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Chemical Structure : ZJU-37
Catalog No.: PC-38621Not For Human Use, Lab Use Only.
ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.
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ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.
ZJU-37 promotes oligodendrocyte progenitor cells (OPCs) proliferation in vitro with higher efficacy than Nec-1s, enhances remyelination in vivo.
ZJU-37 promotes transcription of PDGFRα and proliferation of OPCs via NF-κB.
| M.Wt | 323.708 | |
| Formula | C14H11ClFN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiao-Ru Ma, et al. Cell Death Discov. 2022 Apr 1;8(1):147.
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