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Chemical Structure : ZK824859
CAS No.: 2271122-53-1
Catalog No.: PC-35664Not For Human Use, Lab Use Only.
ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM).
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|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
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ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM).
ZK 824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM.
ZK824859 demonstrates efficacy in either acute or chronic mouse EAE models.
| M.Wt | 428.436 | |
| Formula | C23H22F2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid |
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1. Islam I, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.
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