Chemical Structure : ZL141
CAS No.:
2211973-03-2
ZL141
(ZL-141)
Catalog No.: PC-26654Not For Human Use, Lab Use Only.
ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM.
ZL141 counteracts the modulatory effects of GSK3β on Nav1.6 currents, likely by interfering with the kinase's complex actions on Nav1.6 channels.
ZL141 modulates kinetic properties of Nav1.6 channels.
ZL141 reduces the intrinsic excitability of medium spiny neurons (MSNs) of the nucleus accumbens (NAc) through a GSK3β-dependent mechanism.
Physicochemical Properties
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M.Wt
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508.62
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Formula
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C28H36N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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benzyl ((S)-1-(((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
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References
1. Aditya K Singh, et al. Br J Pharmacol. 2026 Apr 28. doi: 10.1111/bph.70458.
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