Chemical Structure : ZL192
CAS No.:
2227151-36-0
ZL192
(ZL-192)
Catalog No.: PC-25070Not For Human Use, Lab Use Only.
ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons.
ZL192 has no agonist activity against the FGF13R110A/Nav1.7 complex.
ZL192 binds to both FGF13 at Arg110 and Nav1.7 CTD at M1830, binds to FGF13 with SPR KD of 4 μM.
ZL192 exerts regulatory effects on Nav1.7 currents only in HEK-Nav1.7 cells coexpressing FGF13 with EC50 of 8.5 uM.
ZL192 and FGF13 overexpression sensitize Na+ currents in hIPSC-derived sensory neurons and are pronociceptive, without triggering stimuli.
ZL192 exhibits pronociceptive roles that are prevented by in vivo FGF13 silencing and recapitulated in FGF13 overexpression.
Physicochemical Properties
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M.Wt
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620.80
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Formula
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C34H48N6O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-(acetyl-L-phenylalanyl-L-leucyl)-N-((S)-6-amino-1-oxo-1-(phenylamino)hexan-2-yl)pyrrolidine-2-carboxamide
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References
1. Singh AK, et al. J Clin Invest. 2025 Jul 15;135(14):e183749.
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