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ZLN-005

Chemical Structure : ZLN-005

CAS No.: 49671-76-3

ZLN-005 (ZLN 005, ZLN005)

Catalog No.: PC-45338Not For Human Use, Lab Use Only.

ZLN-005 is a small molecule peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) transcriptional activator, increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase (AMPK).

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5 mg (Free Sample) $28 In stock
25 mg $128 In stock
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100 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZLN-005 is a small molecule peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) transcriptional activator, increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase (AMPK).
ZLN-005 improves glucose uptake and fatty acid oxidation without obvious cytotoxicity in L6 myotubes.
ZLN-005 produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice.

Physicochemical Properties

M.Wt 250.3382
Formula C17H18N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 47 mg/mL

Chemical Name/SMILES

1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-

References

1. Zhang LN, et al. Diabetes. 2013 Apr;62(4):1297-307.

2. Kadlec AO, et al. Hypertension. 2017 Jul;70(1):166-173.

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