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ZLWH-23

Chemical Structure : ZLWH-23

CAS No.: 2765251-12-3

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ZLWH-23 (ZLWH23)

Catalog No.: PC-28135Not For Human Use, Lab Use Only.

ZLWH-23 is a selective acetylcholinesterase (AChE) inhibitor with IC50 of 0.27 uM, also inhibits glycogen synthase kinase-3 (GSK-3β) with IC50 of 6.78 uM, possesses selectivity for AChE over BChE and for GSK-3β over multi-kinases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZLWH-23 is a selective acetylcholinesterase (AChE) inhibitor with IC50 of 0.27 uM, also inhibits glycogen synthase kinase-3 (GSK-3β) with IC50 of 6.78 uM, possesses selectivity for AChE over BChE and for GSK-3β over multi-kinases.
ZLWH-23 has very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines.
ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model.

Physicochemical Properties

M.Wt 513.62
Formula C30H32FN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9H-Pyrido[3,4-b]indole-7-carboxamide, 1-[(cyclopropylcarbonyl)amino]-N-[2-[1-[(2-fluorophenyl)methyl]-4-piperidinyl]ethyl]-

References

1. Liu W, et al. Eur J Med Chem. 2022;229:114095.

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