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ZLY032

Chemical Structure : ZLY032

CAS No.: 2314465-67-1

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ZLY032 (ZLY-032)

Catalog No.: PC-24881Not For Human Use, Lab Use Only.

ZLY032 (ZLY-032) is a potent, selective dual FFA1/PPARδ agonist with EC50 of 68 nM and 102 nM for hFFA1 and hPPARδ respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZLY032 (ZLY-032) is a potent, selective dual FFA1/PPARδ agonist with EC50 of 68 nM and 102 nM for hFFA1 and hPPARδ respectively.
ZLY032 has high selectivity over other PPARs.
ZLY032 exhibits good PK profiles with high plasma exposure, which ensured the enough effective concentration to simultaneously activate FFA1 and PPARδ in vivo.
ZLY032 (100 mg/kg) exhibited significantly glucose-lowering effect in ob/ob mice.

Physicochemical Properties

M.Wt 449.44
Formula C22H18F3NO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Benzofuranacetic acid, 2,3-dihydro-6-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]-, (3S)-

References

1. Li Z, et al. Pharmacol Res. 2020 Sep;159:105035.

2. Zheng Li, et al. Eur J Med Chem. 2019 Feb 15:164:352-365.

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