Catalog No.: PC-35678Not For Human Use, Lab Use Only.
ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
ZLc002 exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons.
ZLc002 also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells.
ZLc002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
ZLc002 suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).
Physicochemical Properties
M.Wt
231.248
Formula
C10H17NO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Methyl (3-methoxy-3-oxopropanoyl)-L-valinate
References
1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
