Chemical Structure : ZLc002
CAS No.: 308277-46-5
Catalog No.: PC-35678Not For Human Use, Lab Use Only.
ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
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ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
ZLc002 exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons.
ZLc002 also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells.
ZLc002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
ZLc002 suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).
M.Wt | 231.248 | |
Formula | C10H17NO5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Methyl (3-methoxy-3-oxopropanoyl)-L-valinate |
1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
2. Zhu LJ, et al. Nat Med. 2014 Sep;20(9):1050-4.
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