ZMF-10

Chemical Structure : ZMF-10

Catalog No.: PC-28228Not For Human Use, Lab Use Only.

ZMF-10 is a potent, selective p21-Activated kinase 1 (PAK1) inhibitor with IC50 of 174 nM.

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Biological Activity

ZMF-10 is a potent, selective p21-Activated kinase 1 (PAK1) inhibitor with IC50 of 174 nM.
ZMF-10 inhibits PAK1-ERK signaling to suppress MDA-MB-231 cells proliferation with an IC50 value of 3.48 μM for 48 h.
ZMF-10 induced significant ER-Stress, suppressed migration via FOXO3 activation, JNK1/2, ERK1/2 and AKT signaling inhibition.

Physicochemical Properties

M.Wt	473.38
Formula	C19H17F6N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperidin-4-yl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

References

1. Jin Zhang, et al. Eur J Med Chem. 2020 May 15:194:112220.

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ZMF-10

Biological Activity

Physicochemical Properties

References

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