ZMF-28

Chemical Structure : ZMF-28

Catalog No.: PC-28227Not For Human Use, Lab Use Only.

ZMF-28 is a potent, highly selective p21-Activated kinase 1 (PAK1) inhibitor with IC50 of 0.01 uM.

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Biological Activity

ZMF-28 is a potent, highly selective p21-Activated kinase 1 (PAK1) inhibitor with IC50 of 0.01 uM.
ZMF-28 exhibits 10-fold higher cellular antiproliferative activity against 4T1 cells (IC50=0.22 uM) than FRAX-486.
ZMF-28 achieved significant tumor growth inhibition in vivo without overt toxicity, and demonstrated favorable pharmacokinetics.
ZMF-28 directly binds to PAK1 and blocks its kinase activity, thereby downregulating PD-L1 expression and reversing the immunosuppressive tumor microenvironment, representing a dual-action therapeutic strategy for TNBC.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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ZMF-28

Biological Activity

Physicochemical Properties

References

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