Chemical Structure : ZN148
CAS No.:
2190527-04-7
ZN148
(APC148)
Catalog No.: PC-27134Not For Human Use, Lab Use Only.
ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales.
ZN148 (APC148) potentiates the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model.
ZN148 shows no inhibition of the human zinc-containing enzyme glyoxylase II at 500 uM.
ZN148 restored the bactericidal activity of meropenem against an NDM-1-producing K. pneumoniae strain.
ZN148 potentiates the activity of meropenem in vivo with no acute toxicity in vivo.
Physicochemical Properties
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M.Wt
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511.58
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Formula
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C26H33N5O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-((bis(pyridin-2-ylmethyl)amino)methyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)nicotinamide
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References
1. Ørjan Samuelsen, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19.
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