ZNL-0056 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : ZNL-0056

ZNL-0056 (ZNL0056)

Catalog No.: PC-28718Not For Human Use, Lab Use Only.

ZNL-0056 is a potent, bident, ATP-competitive inhibitor targets both the Cys797 and Cys775 in the ATP binding site of EGFR, demonstrates antiproliferative activity and downstream signaling in mutant EGFR Ba/F3 cells.

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Biological Activity

ZNL-0056 is a potent, bident, ATP-competitive inhibitor targets both the Cys797 and Cys775 in the ATP binding site of EGFR, demonstrates antiproliferative activity and downstream signaling in mutant EGFR Ba/F3 cells.

Physicochemical Properties

M.Wt	477.58
Formula	C25H27N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Thiophenecarboxamide, N-[1-[(3R)-hexahydro-1-(1-oxo-2-propen-1-yl)-1H-azepin-3-yl]-7-methyl-1H-benzimidazol-2-yl]-5-[(1-oxo-2-propen-1-yl)amino]-

References

1. Zhengnian Li, et al. ACS Cent Sci. 2024 Feb 26;10(6):1156-1166.

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ZNL-0056 (ZNL0056)

Biological Activity

Physicochemical Properties

References

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