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Chemical Structure : ZQ-16
CAS No.: 376616-73-8
Catalog No.: PC-60642Not For Human Use, Lab Use Only.
ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.
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ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.
ZQ-16 does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120.
ZQ-16 increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM.
ZQ-16 activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction.
ZQ-16 reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.
| M.Wt | 228.31 | |
| Formula | C10H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(hexylthio)pyrimidine-4,6-diol |
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1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44.
2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.
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