ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.
ZQ-16 does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120.
ZQ-16 increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM.
ZQ-16 activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction.
ZQ-16 reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.
Physicochemical Properties
M.Wt
228.31
Formula
C10H16N2O2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(hexylthio)pyrimidine-4,6-diol
References
1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44.
2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.
