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ZRMQ-22

Chemical Structure : ZRMQ-22

CAS No.:

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ZRMQ-22 (ZRMQ22)

Catalog No.: PC-26298Not For Human Use, Lab Use Only.

ZRMQ-22 is a highly potent DYRK1A inhibitor with IC50 of 0.35 nM, concentration-dependently inhibits nitric oxide (NO) production in LPS-stimulated BV2 cells with IC50 of 1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZRMQ-22 is a highly potent DYRK1A inhibitor with IC50 of 0.35 nM, concentration-dependently inhibits nitric oxide (NO) production in LPS-stimulated BV2 cells with IC50 of 1 uM.
ZRMQ-22 (1 uM) significantly suppressed the secretion of pro-inflammatory cytokines TNF-α and IL-6, with inhibition rates of 64.99% and 114.35%, respectively.
ZRMQ-22 effectively reduced levels of inflammatory markers and improved cognitive function in an LPS-induced neuroinflammation mouse model using C57BL/6 mice.

Physicochemical Properties

M.Wt 436.52
Formula C26H24N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(5-(2-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(piperidin-1-yl)quinazoline

References

1. Ren M, et al. RSC Med Chem. 2026 Feb 20. doi: 10.1039/d6md00007j.

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