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ZSA-215

Chemical Structure : ZSA-215

CAS No.:

ZSA-215 (ZSA215)

Catalog No.: PC-24802Not For Human Use, Lab Use Only.

ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.
ZSA-215 displays potent activity for STINGR232 (EC50 = 9.0 μM) and mSTING (EC50 = 9.3 μM) in THP1 cells, also has significant STING WT binding affinity.
ZSA-215 does not induce interferon response in THP1 (STINGKO) cells.
ZSA-215 dramatically induces the expression of IFN-β, significantly increases the phosphorylation of STING and IRF3.
ZSA-215 (60 mg/kg, PO) dramatically suppressed tumor growth in MC38 tumor model.

Physicochemical Properties

M.Wt 402.28
Formula C16H18FNO5Se
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-((3-Fluoro-5,6-dimethoxybenzo[b]selenophene-2-carboxamido)methyl)butanoic Acid

References

1. Zhao HY, et al. J Med Chem. 2025 May 29. doi: 10.1021/acs.jmedchem.5c00296.

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