Chemical Structure : ZSA-215
CAS No.:
ZSA-215
(ZSA215)
Catalog No.: PC-24802Not For Human Use, Lab Use Only.
ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.
ZSA-215 displays potent activity for STINGR232 (EC50 = 9.0 μM) and mSTING (EC50 = 9.3 μM) in THP1 cells, also has significant STING WT binding affinity.
ZSA-215 does not induce interferon response in THP1 (STINGKO) cells.
ZSA-215 dramatically induces the expression of IFN-β, significantly increases the phosphorylation of STING and IRF3.
ZSA-215 (60 mg/kg, PO) dramatically suppressed tumor growth in MC38 tumor model.
Physicochemical Properties
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M.Wt
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402.28
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Formula
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C16H18FNO5Se
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-2-((3-Fluoro-5,6-dimethoxybenzo[b]selenophene-2-carboxamido)methyl)butanoic Acid
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References
1. Zhao HY, et al. J Med Chem. 2025 May 29. doi: 10.1021/acs.jmedchem.5c00296.
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