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ZSET1446

Chemical Structure : ZSET1446

CAS No.: 887603-94-3

ZSET1446 (ST101;ZSET-1446;ZSET 1446;ST-101;ST 101)

Catalog No.: PC-42788Not For Human Use, Lab Use Only.

ZSET1446 (ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZSET1446 (ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons.
ZSET1446 (ST-101) increases the extracellular ACh in the cortex and hippocampus and enhances nicotine-stimulated ACh release in the hippocampus in normal rats, without affecting nAChRs.

Physicochemical Properties

M.Wt 236.2686
Formula C15H12N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-

References

1. Yamaguchi Y, et al. J Pharmacol Exp Ther. 2006 Jun;317(3):1079-87.

2. Ito Y, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):819-27.

3. Han F, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):127-34.

4. Shioda N, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):43-50.

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