ZSL-M028

Chemical Structure : ZSL-M028

Catalog No.: PC-27332Not For Human Use, Lab Use Only.

ZSL-M028 is a potent and selective, orally active Polo-like kinase 4 (PLK4) inhibitor with IC50 of 1.1 nM, has 1600-fold selectivity over Aurora A, demonstrates significant in vitro and in vivo antitumor activity against TRIM37-amplified neuroblastoma.

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Biological Activity

Physicochemical Properties

M.Wt	505.53
Formula	C27H29FN5O2P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-fluoro-2-(((2-((4-morpholinophenyl)amino)quinazolin-7-yl)amino)methyl)phenyl)dimethylphosphine oxide

References

1. Liu N, et al. J Med Chem. 2026 Jul 16. doi: 10.1021/acs.jmedchem.6c01348.

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ZSL-M028

Biological Activity

Physicochemical Properties

References

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