Chemical Structure : ZSTK3744 hydrochloride
CAS No.:
3106975-39-4
ZSTK3744 hydrochloride
Catalog No.: PC-26117Not For Human Use, Lab Use Only.
ZSTK3744 hydrochloride is a small molecule Aryl hydrocarbon receptor (AhR) agonist, exhibits cell growth inhibitory activity with IC50 of 0.87 nM for chemotherapy-resistant TNBC MDA-MB-468 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZSTK3744 hydrochloride is a small molecule Aryl hydrocarbon receptor (AhR) agonist, exhibits cell growth inhibitory activity with IC50 of 0.87 nM for chemotherapy-resistant TNBC MDA-MB-468 cells.
ZSTK3744 exerts its cell growth-inhibitory activity through an apoptosis-mediated mechanism.
ZSTK3744 demonstrates more potent efficacy than adriamycin, paclitaxel, and eribulin in chemotherapy-resistant cells.
ZSTK3744 significantly reduces the viability of MM468, MM453, and DU4475 cells.
ZSTK3744 induces CYP1A1 and CYP1B1 mRNA expression in MM468, MM453, and DU4475 cells.
ZSTK3744 administration at 2.5 and 5 mg/kg significantly reduced the tumor volume in MM468-transplanted mice.
Physicochemical Properties
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M.Wt
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417.90
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Formula
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C22H20ClN7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-7-methyl-2-(4-methyl-1H-benzo[d]imidazol-1-yl)-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
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References
1. Takahiro Ohashi, et al. Cancer Res Commun. 2026 Feb 1;6(2):421-436.
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