Chemical Structure : ZW-1226
CAS No.:
ZW-1226
(ZW1226)
Catalog No.: PC-22756Not For Human Use, Lab Use Only.
ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.
ZW-1226 is 16 times more potent than the known MRP1 inhibitor MK-571 in vesicular transport assay.
ZW-1226 shows good selectivity for MRP1 over other major ABC transporters, including P-gp, BCRP, MRP2 and MRP3.
ZW-1226 effectively reversed MRP1-mediated drug resistance to TOP2 poisons etoposide and doxorubicin in H69AR cells.
ZW-1226 exhibited high tissue to plasma partitioning in mice without altering etoposide distribution to normal tissues.
Physicochemical Properties
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M.Wt
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422.44
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Formula
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C25H18N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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10-(4-(benzyloxy)phenyl)-2,4-dioxo-2,3,4,4a,5,10-hexahydropyrimido[4,5-b]quinoline-8-carbonitrile
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References
1. Belhadj Z, et al. Biomed Pharmacother. 2024 Jul 19;178:117167.
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