Chemical Structure : ZW-2038
CAS No.:
ZW-2038
(ZW2038)
Catalog No.: PC-27149Not For Human Use, Lab Use Only.
ZW-2038 is a potent antiviral compound against orthopoxviruses vaccinia virus (VACV), monkeypox virus (MPXV), and cowpox virus (CPXV), inhibits VACV replication inhibitor in primary HFFs with EC50 of 876 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZW-2038 is a potent antiviral compound against orthopoxviruses vaccinia virus (VACV), monkeypox virus (MPXV), and cowpox virus (CPXV), inhibits VACV replication inhibitor in primary HFFs with EC50 of 876 nM.
ZW-2038 suppresses VACV DNA replication and downstream gene expression but not early gene replication, suppresses VACV replication by interfering with VACV DNA replication, which in turn prevents the expression of downstream intermediate and late genes.
ZW-2038 (10 μM) significantly inhibits MPXV and CPXV replication in primary HFFs.
ZW-2038 reduces VACV replication in human and non-human primate enteroids and in ex vivo lung tissue models.
ZW-2038 does not inhibit MPXV resolvase in vitro.
Physicochemical Properties
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M.Wt
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402.37
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Formula
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C21H17F3N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2,4-difluorophenethyl)-1-(4-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxamide
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References
1. Pant A, et al. Antimicrob Agents Chemother. 2026 Jun 18:e0192225.
2. Senaweera S, et al. Acta Pharm Sin B 12:1671–1684.
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