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Chemical Structure : ZX703
Catalog No.: PC-22066Not For Human Use, Lab Use Only.
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%.
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ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%.
ZX703 exhibits HT1080 cell growth inhibition with IC50 of 435 nM.
ZX703 significantly degrades GPX4 through the ubiquitin–proteasome and the autophagy–lysosome pathways in a dose- and time-dependent manner.
ZX703 induces ROS accumulation in a dose-dependent manner, subsequently leading to ferroptosis in HT1080 cells.
| M.Wt | 1039.69 | |
| Formula | C54H67ClN8O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hu M, et al. ACS Med Chem Lett. 2024 Feb 15;15(3):406-412.
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