Chemical Structure : ZX703
CAS No.:
ZX703
(ZX-703, ZX 703)
Catalog No.: PC-22066Not For Human Use, Lab Use Only.
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%.
ZX703 exhibits HT1080 cell growth inhibition with IC50 of 435 nM.
ZX703 significantly degrades GPX4 through the ubiquitin–proteasome and the autophagy–lysosome pathways in a dose- and time-dependent manner.
ZX703 induces ROS accumulation in a dose-dependent manner, subsequently leading to ferroptosis in HT1080 cells.
Physicochemical Properties
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M.Wt
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1039.69
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Formula
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C54H67ClN8O9S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-((2S)-2-(10-(4-((4-Chlorophenyl)(4-(5-methyl-4-nitroisoxazole-3-carbonyl)piperazin-1-yl)methyl)phenoxy)decanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
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References
1. Hu M, et al. ACS Med Chem Lett. 2024 Feb 15;15(3):406-412.
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